Description

• Obesity is a term used to describe body weight that is much greater than what is considered healthy. It has become a serious public health problem. It affects 32.2% of the global population. The worldwide prevalence of obesity is 1.6 billion and is already reached epidemic proportions mostly in high income groups. Strategies involve general lifestyle modification includes healthy diet, maintain optimal weight,physical activity etc. Non-pharmacological therapy consists of diet and exercise, but most of the cases this form of therapy may not be helpful to reduce weight antisfactorily. The available synthetic Pharmacological therapies having its own side effects and limitations. herbal Medicine plays an important role in the management of obesity. Number of herbs is documented in ayurveda classics to reduce weight trimosky liquid and skynotrim capsule contains hydroxy citric  acid  which is known as weight reducing agent. applications are based on the fact that in the body carbohydrates of the food are broken down into glucose which is stored as glycogen. When glycogen storage is saturated, excess glucose is converted into fat and cholesterol. Garcinia cambogia extract inhibit body’s conversion of glucose into fat and cholesterol by inhibiting certain enzyme process . The increase in glycogen stores, help significantly reduce cravings for food, reduce appetite and induce weight loss
• Blocking the enzyme ATP – Citrate Lyase HCA reduces the conversion of carbohydrate calories into fats. It does this by inhibiting the actions of ATP – Citrate lyase, the enzyme that converts citrate into fatty acids and cholesterol in the primary pathway of fat synthesis.

ATP citrate lyase

Citrate + COA+ATP                                                           acetyl CoA + oxalo acetate + ADP+PI

• Acetyl co-e 4nzyme A is a precurser of fatty acids  by inhibiting the formation of Acetyl co-enzyme A ,fatty acid synthesis is controlled.
• The actlons of HCA increase the production and storage of glycogen (which1s found in the liver, small intestine and muscles) while reducing both appetite and weight gain

     2.Inhibiting Lipogenesis By inhibiting the actions of ATP-Citrate lyase, HCA reduces the availability of acetyl coenzyme A, the building block for fatty acid and cholesterol synthesis [Greenwood and Robinson, 19991. This may also cause the body to remove low density lipoprotein (LDL) from the blood. Effect of HCA on fatty acid synthesis and insulin release was studied by Sener and Malaisse. The reduction in cholesterol synthesis is greater than the reduction in fatty acid synthesis. Animal trials have resulted in the reduction of triglycerides, cholesterol, food consumption and weight gain. Similar results were obtained when chromium was added to HCA in the diet

Trikatu , Trimard , Triphala and Shuddha guggul has great inti-obesity property and its importance also mentioned in ayurveda.